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Nielsen,SF., Boesen,T., Larsen,M., Schønning,C. and Kromann,H. Antibacterial chalcones - bioisosteric replacement of the 4'-hydroxy group. Bioorganic & Medicinal Chemistry. 12:3047-3054. 2004.

Chen, M., Klaumünzner, J.A., Zhai, L., Kharazmi, A. and Jensen, J. Effect of antimalarial licochalcone A on the electron transport chain of Plasmodium falciparum and Plasmodium berghei. Proceedings of the 10th International Congress of Parasitology - ICOPA X:493-498. 2002.

Friis-Møller, A., Chen, M., Fuursted, K.,  Christensen,S.B. and Kharazmi,A. In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots. Planta Medica 68:416-419. 2002.

Chen,M., Bennedsen,M., Zhai,L. and Kharazmi,A. Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Lesihmania parasites. APMIS. 109:801-808. 2001.

Chen, M., Zhai, L., Christensen, S.B., Theander, T.G., and Kharazmi, A. Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones. Antimicrob. Agents and Chemother. 45:2023-2029. 2001.

Christensen, S.B. and Kharazmi, A. Antimalarial natural products. In: Bioactive Natural products: Isolation, structure elucidation and biological properties. (Ed. C. Tringali). Taylor & Francis Ltd. London. Pp.379-432. 2001.

Zhai, L., Chen, M., Blom, J., Theander, T.G., Christensen, S.B., and Kharazmi, A. The antileishmanial acitivity of novel oxygenated chalcones and their mechanism of action. J. Antimicrobial Chemother. 43:793-803. 1999.

Nielsen, S.F., Christensen,S.B., Cruciani,G. Kharazmi,A., and Liljefors,T. Antileishmanial chalcones: Statistical design, synthesis and three-dimentional quantitative structure-activity relationship analysis. J. Medicinal. Chem. 41:4819-4832. 1998.

Nielsen, S.F., Kharazmi, A., and Brøgger Christensen, S. Modifications of the a,b-double bond in chalcones only marginally affect the antiprotozoal activities. Bioorg. Med. Chem. 6:937-945. 1998.

Nadelmann,L., Tjornelund, J., Christensen, E. and Hansen, S.H. High-performance liquid chromatographic determination of licochalcone A and its metabolites in biological fluids. J Chromatogr B Biomed Sci Appl. 695(2): 389-400. 1997.

Nadelmann, L., Tjornelund, J, Hansen, S.H., Cornett, C., Sidelmann, U.G., Braumann, U., Christensen, E., and Christensen, SB. Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A. Xenobiotica. 27(7): 667-80. 1997.

Chen, M., Christensen, S.B., Zhai, L., Rasmussen, M., Theander, T.G., Frøkjær, S., Steffansen, B., Davidsen, J., and Kharazmi, A. The Novel oxygenated chalcone 2,4 dimethyloxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodnet parasites Plasmodium berghei and Plasmodium yoelii in vivo. J. Infect. Dis. 176:1327-1333. 1997.

Kharazmi, A., Chen, M., Theander, T. and Christensen, S.B. Discovery of oxygenated chalcones as novel antimalarial agents. Annals Trop. Med. Parasitol. 91, Suppl. 1:S91-S95. 1997.

Nielsen, S. F., Chen, M.; Theander, T. G., Kharazmi, A., Christensen, S. B. Synthesis of Antiparasitic Licorice Chalcones. Bioorg. Med. Chem. Lett. 5:449-452. 1995.

Chen, M. Antileishmanial and antimalrail activities of licochalcone A. Ugeskrift for Læger (Danish). 157, 4469. 1995.

Chen, M. Antileishmanial and antimalrail activities of licochalcone A. Danish Medical Bulletin. 42, 378. 1995.

Kharazmi, A., Chen, M., Christensen, S.B., & Theander, T.G. Discovery and Development of Novel Antiprotozoal Agents. Sudan Med. J. 33, 55-61. 1995.

Zhai, L., Blom, J., Chen, M., Brøgger Christensen, S., and Kharazmi, A.  The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria. Antimicrobial Agents and Chemotherapy. 39:2742-2748. 1995. 

Chen, M., Kappel, M., Lemnge, M., Bygbjerg, I.C., Theander, T.G. and Kharazmi, A. In vitro effects of artesunate and other antimalarial agents on the function of human lymphocytes and neutrophils. Transplantation Proceedings 26:3172-3174. 1994.

Chen, M., Theander, T.G., Brøgger Christensen, S., Hviid, L. and Kharazmi, A. Licochalcone A, a new antimalarial agent inhibits the in vitro growth of the human parasite Plasmodium falciparum  and protects mice from P. yoelii infection. Antimicrob. Agents Chemother. 38:1470-1475. 1994.

Chen,M., Brøgger Christensen,S., Nadelmann,L., Fich,K., Lemmich,E., Blom,J., Theander,T.G., and Kharazmi,A. Licochalcone A, a novel antileishmanial agent with potent activity against human pathogenic protozoan Leishmania. Antimicrob. Agents Chemother. 37:2550-2556. 1993.           

Ph.D. theses:

  1. Chen, M. Antileishmanial and antimalarial activities of licochalcone A. Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark. April, 1995.
  2. Nadelmann, L. Investigations of the metabolism of licochalcone A, a novel antiparasitic agent, using separation techniques. Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharamacy. February, 1997.
  3. Nielsen, S.F. Antiparasitære chalconer: Struktur-aktivitets relationer. Department of Medicinal Chemistry, The Royal Danish School of Pharamacy. June, 1997.
  4. Zhai, L. Mechanism of action of oxygenated chalcones on human pathogenic protozoan Leishmania. Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark. November, 1998.

 

   
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